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Collaborative Agreements (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Sep. 30, 2015
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Collaborative Agreements        
Cost of product sales   $ 78,509 $ 20,306 $ 11,960
Deferred revenues, long-term   5,093    
Velo Bio option agreement        
Collaborative Agreements        
Upfront payment for option to acquire global rights to DIF program $ 10,000      
Payments due if the option to acquire the global rights to the DIF program is exercised   65,000    
Velo Bio option agreement | Maximum        
Collaborative Agreements        
Sales milestone payments based on annual sales milestones   250,000    
Sales milestone targets   900,000    
Velo Bio option agreement | Minimum        
Collaborative Agreements        
Sales milestone targets   100,000    
License Development and Commercialization Agreement with Takeda [Member]        
Collaborative Agreements        
Other reimbursement revenues     1,700 $ 500
Product sales and royalty revenue recognized   1,100 3,500  
Cost of product sales     $ 2,800  
License Development and Commercialization Agreement with Takeda [Member] | Termination Agreement        
Collaborative Agreements        
Deferred revenue recognized in earnings related to the amortization of the deferred revenue balance   44,400    
Additional revenue recognized related to Takeda   $ 6,700