Income Taxes - Deferred tax components (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Assets
Net operating loss carryforwards	$ 172,944	$ 188,873
Tax credit carryforwards	6,262	24,574
Deferred revenue	626	17,216
Equity-based compensation expense	5,464	3,436
Capitalized research & development	25,216	32,359
Intangibles		272
Debt instruments		731
Reserves	8,900	7,782
Property, plant and equipment		61
Other	10,894	5,014
Liabilities
Property, plant, and equipment depreciation	(2,844)
Intangible assets and inventory	(400,357)	(290,491)
Debt instruments	(1,213)
Other	(3,178)	(1,795)
Net deferred tax liability	(177,286)	(11,968)
Valuation allowance	(11,859)	(33,557)
Net deferred taxes	(189,145)	$ (45,525)
Valuation Allowance
Decrease in valuation allowance	$ 21,700