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Current and Long- Term Liabilities (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Accrued Expenses    
Commercial rebates, fees and returns $ 45,161 $ 44,807
Professional, license, and other fees and expenses 27,070 15,857
Interest expense 18,411 7,300
Salaries, bonuses, and other compensation 12,838 10,176
Restructuring expense 2,883 1,953
Total accrued expenses 106,363 $ 80,093
Takeda Upfront Payments and Milestone Payments Recognized | License Fee, Collaboration and Other Revenues    
Deferred Revenues    
Deferred revenue recognized in earnings related to the amortization of the deferred revenue balance $ 44,400