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Fair Value Measurements - Contingent Consideration (Details) - USD ($)
$ in Thousands
12 Months Ended
Nov. 12, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Jun. 06, 2013
Reconciliation of contingent consideration obligations related to acquisitions          
Acquisition-related contingent consideration     $ 205,000 $ 13,700  
Adjustments to fair value of contingent consideration   $ 4,271 (681) $ 1,074  
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3          
Reconciliation of contingent consideration obligations related to acquisitions          
Discount rate (as a percent)       15.00%  
Lumara Health and MuGard Rights | Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3          
Reconciliation of contingent consideration obligations related to acquisitions          
Balance at beginning of period   218,702 14,550    
Payments made   (456) (270)    
Adjustments to fair value of contingent consideration   4,271 (681)    
Other adjustments   42 103    
Balance at end of period   222,559 218,702 $ 14,550  
Lumara Health          
Reconciliation of contingent consideration obligations related to acquisitions          
Acquisition-related contingent consideration $ 205,000        
Adjustments to fair value of contingent consideration   8,300 1,600    
Estimated undiscounted milestone amounts payable   350,000      
Discount rate (as a percent) 5.00%        
Contingent consideration classified as short term liability   $ 96,400      
Interest rate (as a percent)   5.00%      
Lumara Health | Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3          
Reconciliation of contingent consideration obligations related to acquisitions          
Acquisition-related contingent consideration     205,000    
MuGard          
Reconciliation of contingent consideration obligations related to acquisitions          
Acquisition-related contingent consideration         $ 13,700
Adjustments to fair value of contingent consideration   $ (4,000) $ (2,300)    
Period over which estimated undiscounted royalty amounts could be paid   10 years      
Discount rate (as a percent)   12.00%      
Contingent consideration classified as short term liability   $ 600      
MuGard | Minimum          
Reconciliation of contingent consideration obligations related to acquisitions          
Estimated undiscounted royalty amounts payable   9,000      
MuGard | Maximum          
Reconciliation of contingent consideration obligations related to acquisitions          
Estimated undiscounted royalty amounts payable   $ 13,000