Business Combination - Activity - MuGard (Details) - USD ($) $ in Thousands		12 Months Ended
	Jun. 06, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Consideration:
Acquisition-related contingent consideration			$ 205,000	$ 13,700
Assets Acquired
Acquisition-related costs		$ 11,232	$ 9,478	$ 782
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3
Fair value inputs
Discount rate (as a percent)				15.00%
MuGard
Acquired Finite-Lived Intangible Assets [Line Items]
Upfront payment in consideration of license	$ 3,300
Consideration:
Cash consideration	3,434
Acquisition-related contingent consideration	13,700
Total purchase price	17,134
Fair value inputs
Discount rate (as a percent)		12.00%
Assets Acquired
Finite-lived intangible assets	16,893
Inventory	241
Total assets acquired	$ 17,134
Acquisition-related costs				$ 800
MuGard | Minimum
Fair value inputs
Estimated undiscounted royalty amounts payable		$ 9,000
MuGard | Maximum
Fair value inputs
Estimated undiscounted royalty amounts payable		$ 13,000