CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
U.S. product sales, net	$ 341,816	$ 109,998	$ 71,692
Service revenues, net	24,132
License fee and other collaboration revenues	52,328	14,386	9,164
Total revenues	418,276	124,384	80,856
Costs and expenses:
Cost of product sales	78,509	20,306	11,960
Cost of services	9,992
Research and development expenses	42,878	24,160	20,564
Selling, general and administrative expenses	160,309	72,254	59,167
Acquisition-related costs	11,232	9,478	782
Restructuring expenses	4,136	2,023
Total costs and expenses	307,056	128,221	92,473
Operating income (loss)	111,220	(3,837)	(11,617)
Other income (expense):
Interest expense	(53,251)	(14,697)
Loss on debt extinguishment	(10,449)
Interest and dividend income, net	1,512	975	1,051
Other income (expense)	(9,188)	217	964
Total other income (expense)	(71,376)	(13,505)	2,015
Net income (loss) before income taxes	39,844	(17,342)	(9,602)
Income tax expense (benefit)	7,065	(153,159)
Net income (loss)	$ 32,779	$ 135,817	$ (9,602)
Net income (loss) per share:
Basic	$ 1.04	$ 6.06	$ (0.44)
Diluted	$ 0.93	$ 5.45	$ (0.44)
Weighted average shares outstanding used to compute net income (loss) per share:
Basic	31,471	22,416	21,703
Diluted	35,308	25,225	21,703