CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014
Cash flows from operating activities:
Net income (loss)	$ 25,578	$ (7,191)
Adjustments to reconcile net income ( loss) to net cash provided by (used in) operating activities:
Depreciation and amortization	51,346	655
Amortization of premium/discount on purchased securities	1,505	1,823
Write-down of inventory to net realizable value	869	1,119
Gain (loss) on disposal of property and equipment		(102)
Non-cash equity-based compensation expense	11,572	6,153
Loss on debt extinguishment	6,426
Amortization of debt discount and debt issuance costs	8,463	4,531
Gains on investments, net	(2)	(17)
Change in fair value of contingent consideration	4,525	(2,535)
Deferred income taxes	17,557
Changes in operating assets and liabilities:
Accounts receivable, net	(24,075)	(4,031)
Inventories	(1,013)	(2,496)
Receivable from collaboration	4,518	(654)
Prepaid and other current assets	(89)	(2,211)
Other long-term assets	5,959	1,001
Accounts payable and accrued expenses	(4,013)	87
Other short-term liabilities	(1,688)
Deferred revenues	(35,575)	(6,659)
Other long-term liabilities	(1,288)	137
Repayment of term loan attributable to original issue discount	(12,491)
Net cash provided by (used in) operating activities	58,084	(10,390)
Cash flows from investing activities:
Acquisition of Lumara Health, net of acquired cash	562
Acquisition of CBR, net	(682,163)
Proceeds from sales or maturities of investments	74,021	58,592
Purchase of investments	(326,080)	(63,747)
Change in restricted cash	(3)	2,883
Capital expenditures, net of proceeds from sale of assets	(440)	(42)
Net cash (used in) investing activities	(934,103)	(2,314)
Cash flows from financing activities:
Proceeds from the issuance of common stock, net of underwriting discounts and other expenses	407,477
Long-term debt principal payments	(327,509)
Proceeds from issuance of convertible 2.5% notes		200,000
Proceeds from long-term debt	839,125
Payment of debt issuance costs	(10,000)	(6,711)
Proceeds from issuance of warrants		25,620
Purchase of convertible bond hedges		(39,760)
Payment of contingent consideration	(322)	(186)
Proceeds from the exercise of stock options	15,482	2,909
Net cash provided by financing activities	924,253	181,872
Net increase in cash and cash equivalents	48,234	169,168
Cash and cash equivalents at beginning of the period	119,296	26,986
Cash and cash equivalents at end of the period	167,530	196,154
Supplemental data of cash flow information:
Cash paid for taxes	1,794
Cash paid for interest	$ 23,766	$ 2,514