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Fair Value Measurements - Contingent Consideration (Details) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Dec. 31, 2014
Feb. 14, 2014
Reconciliation of contingent consideration obligations related to acquisitions        
Balance at beginning of period $ 218,702      
Payments made (322)      
Adjustments to fair value of contingent consideration 4,525 $ (2,535)    
Other adjustments 40      
Balance at end of period $ 222,945      
Interest rate (as a percent) 2.50%   2.50%  
Estimated fair value of long-term debt $ 322,100      
2023 Senior Notes        
Reconciliation of contingent consideration obligations related to acquisitions        
Estimated fair value of long-term debt $ 477,500      
Convertible Debt        
Reconciliation of contingent consideration obligations related to acquisitions        
Aggregate principal amount of debt issued       $ 200,000
Interest rate (as a percent) 2.50%      
Estimated fair value of long-term debt $ 322,100      
Abeona Therapeutics, Inc | Licensing Agreements        
Reconciliation of contingent consideration obligations related to acquisitions        
Period over which estimated undiscounted royalty amounts could be paid 10 years      
Abeona Therapeutics, Inc | Licensing Agreements | Fair Value, Inputs, Level 3        
Reconciliation of contingent consideration obligations related to acquisitions        
Discount rate (as a percent) 12.00%      
Abeona Therapeutics, Inc | Licensing Agreements | Minimum        
Reconciliation of contingent consideration obligations related to acquisitions        
Estimated undiscounted royalty amounts payable $ 10,000      
Abeona Therapeutics, Inc | Licensing Agreements | Maximum        
Reconciliation of contingent consideration obligations related to acquisitions        
Estimated undiscounted royalty amounts payable $ 18,000      
Lumara Health        
Reconciliation of contingent consideration obligations related to acquisitions        
Discount rate (as a percent) 5.00%      
Makena | Licensing Agreements        
Reconciliation of contingent consideration obligations related to acquisitions        
Adjustments to fair value of contingent consideration $ 7,700      
Makena | Abeona Therapeutics, Inc | Licensing Agreements        
Reconciliation of contingent consideration obligations related to acquisitions        
Contingent consideration classified as short term liability 96,100      
MuGard | Abeona Therapeutics, Inc | Licensing Agreements        
Reconciliation of contingent consideration obligations related to acquisitions        
Adjustments to fair value of contingent consideration (3,200)      
MuGard | Lumara Health | Licensing Agreements        
Reconciliation of contingent consideration obligations related to acquisitions        
Contingent consideration classified as short term liability $ 700