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Description of Business (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 9 Months Ended
Aug. 17, 2015
Aug. 05, 2015
Jul. 22, 2015
Aug. 31, 2015
Mar. 31, 2015
Sep. 30, 2015
Dec. 31, 2014
Nov. 12, 2014
Description of Business                
Number of shares sold in an underwritten public offering       3.6 4.6      
Proceeds from the issuance of common stock, net   $ 218,600   $ 218,600 $ 188,800 $ 407,477    
Interest rate (as a percent)           2.50% 2.50%  
Repayments of debt           $ 327,509    
Velo Bio, LLC                
Description of Business                
Upfront payment made related to option to acquire the global rights to the DIF program ("DIF Rights")     $ 10,000          
Maximum payments to be made, upon the exercise of the option to acquire the global rights to the DIF program ("DIF Rights"), excluding sales milestone payments     65,000          
Maximum sales milestone payments to be made based on the achievement of annual sales milestones at specified targets     250,000          
Minimum | Velo Bio, LLC                
Description of Business                
Annual sales milestone target     100,000          
Maximum | Velo Bio, LLC                
Description of Business                
Annual sales milestone target     $ 900,000          
2023 Senior Notes                
Description of Business                
Principal amount of debt issued $ 500,000              
Interest rate (as a percent) 7.875%         7.875%    
2015 Term Loan Facility                
Description of Business                
Principal amount of debt issued $ 350,000              
Debt term 6 years              
2014 Term Loan Facility                
Description of Business                
Principal amount of debt issued               $ 340,000
Debt term 5 years              
Repayments of debt $ 323,000              
Common Stock                
Description of Business                
Number of shares sold in an underwritten public offering   3.6            
Sale price of common stock (in dollars per share)   $ 63.75            
CBR Acquisition Holdings Corp                
Description of Business                
Cash consideration $ 700,000