CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	6 Months Ended
	Jun. 30, 2014	Jun. 30, 2013
Cash flows from operating activities:
Net loss	$ (8,649)	$ (5,803)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	380	1,339
Amortization of premium/discount on purchased securities	1,256	1,369
Write-down of inventory to net realizable value	868	502
Non-cash equity-based compensation expense	4,207	4,221
Amortization of debt discount and debt issuance costs	2,652
Gains on sale of assets	(102)	(865)
Gains on investments, net	(14)	(32)
Change in fair value of contingent consideration	1,178
Changes in operating assets and liabilities:
Accounts receivable, net	(3,739)	(2,080)
Inventories	(2,567)	695
Receivable from collaboration	48	(105)
Prepaid and other current assets	(1,425)	555
Other long-term assets	1,137
Accounts payable and accrued expenses	(515)	(6,089)
Deferred revenues	(5,178)	(3,783)
Other long-term liabilities	227	(227)
Total adjustments	(1,587)	(4,500)
Net cash used in operating activities	(10,236)	(10,303)
Cash flows from investing activities:
Proceeds from sales or maturities of investments	48,706	63,767
Purchase of investments	(47,329)	(69,653)
Acquisition of MuGard Rights and inventory		(3,434)
Proceeds from sale of assets	102	977
Capital expenditures	(135)
Change in restricted cash	2,883	(400)
Net cash provided by (used in) investing activities	4,227	(8,743)
Cash flows from financing activities:
Payment of contingent consideration	(90)
Proceeds from issuance of convertible debt	200,000
Payment of debt issuance costs	(6,711)
Proceeds from issuance of warrants	25,620
Purchase of convertible bond hedges	(39,760)
Proceeds from the exercise of stock options	2,021	379
Proceeds from the issuance of common stock under ESPP		176
Net cash provided by financing activities	181,080	555
Net increase (decrease) in cash and cash equivalents	175,071	(18,491)
Cash and cash equivalents at beginning of the period	26,986	46,293
Cash and cash equivalents at end of the period	$ 202,057	$ 27,802