CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Revenues:
Product sales, net	$ 14,420	$ 13,081	$ 28,128	$ 24,103
License fee and other collaboration revenues	16,592	2,288	18,345	4,615
Royalties		33	19	69
Total revenues	31,012	15,402	46,492	28,787
Costs and expenses:
Cost of product sales	3,224	2,082	5,870	5,123
Research and development expenses	7,671	16,695	20,133	30,261
Selling, general and administrative expenses	15,101	16,826	28,282	36,460
Restructuring expenses	1,058		1,058
Total costs and expenses	27,054	35,603	55,343	71,844
Other income (expense):
Interest and dividend income, net	338	452	731	1,012
Losses on investments, net	(1,471)	(209)	(1,471)	(208)
Total other income (expense)	(1,133)	243	(740)	804
Net income (loss) before income taxes	2,825	(19,958)	(9,591)	(42,253)
Income tax benefit	494	396	494	396
Net income (loss)	$ 3,319	$ (19,562)	$ (9,097)	$ (41,857)
Net income (loss) per share:
Basic (in dollars per share)	$ 0.16	$ (0.92)	$ (0.43)	$ (1.98)
Diluted (in dollars per share)	$ 0.15	$ (0.92)	$ (0.43)	$ (1.98)
Weighted average shares outstanding used to compute net income (loss) per share:
Basic (in shares)	21,370	21,167	21,359	21,156
Diluted (in shares)	21,649	21,167	21,359	21,156