Equity-Based Compensation (Details 2) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Equity-based compensation expense
Total equity-based compensation expense	$ 1,577	$ 2,621	$ 3,262	$ 7,096
Cost of product sales
Equity-based compensation expense
Total equity-based compensation expense	68	157	146	352
Research and development
Equity-based compensation expense
Total equity-based compensation expense	525	639	947	1,281
Selling, general and administrative
Equity-based compensation expense
Total equity-based compensation expense	$ 984	$ 1,825	$ 2,169	$ 5,463