Basis of Presentation and Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2012

Basis of Presentation and Summary of Significant Accounting Policies

Schedule of assets measured at fair value on a recurring basis

	Fair Value Measurements at June 30, 2012 Using:
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Money market funds	$	27,417	$	27,417	$	—	$	—
Corporate debt securities	110,218		—		110,218		—
U.S. treasury and government agency securities	58,876		—		58,876		—
Commercial paper	7,477		—		7,477		—
	$	203,988	$	27,417	$	176,571	$	—

	Fair Value Measurements at December 31, 2011 Using:
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Money market funds	$	55,995	$	55,995	$	—	$	—
Corporate debt securities	94,626		—		94,626		—
U.S. treasury and government agency securities	48,086		—		48,086		—
Commercial paper	5,991		—		5,991		—
Auction rate securities	17,527		—		—		17,527
	$	222,225	$	55,995	$	148,703	$	17,527

Rollforward of assets measured at fair value on a recurring basis using significant unobservable inputs (Level 3)

	Six Months Ended June 30, 2012
Balance at beginning of period	$	17,527
Transfers to Level 3	—
Total gains (losses) (realized or unrealized):
Included in earnings	(1,471		)
Included in other comprehensive income (loss)	2,373
Purchases, issuances, sales and settlements:
Purchases	—
Issuances	—
Sales	(18,329		)
Settlements	(100		)
Balance at end of period	$	—
The amount of total gains (losses) for the period included in earnings attributable to the change in unrealized gains (losses) relating to assets still held at end of period	$	—

Analysis of product sales allowances and accruals

	Three Months Ended June 30,
	2012			2011
Product sales allowances and accruals
Discounts and chargebacks	$	6,846		$	3,579
Government and other rebates	1,672			2,737
Returns	(292		)	369
Total provision for product sales allowances and accruals	$	8,226		$	6,685
Total gross product sales	$	22,646		$	19,766
Total provision for product sales allowances and accruals as a percent of total gross product sales	36		%	34		%

	Six Months Ended June 30,
	2012			2011
Product sales allowances and accruals
Discounts and chargebacks	$	12,738		$	5,799
Government and other rebates	3,132			5,271
Returns	(558		)	668
Total provision for product sales allowances and accruals	$	15,312		$	11,738
Total gross product sales	$	43,440		$	35,841
Total provision for product sales allowances and accruals as a percent of total gross product sales	35		%	33		%

Schedule of customers representing 10% or more of revenues

	Six Months Ended June 30,
	2012		2011
Takeda Pharmaceuticals Company Limited	40	%	16	%
AmerisourceBergen Drug Corporation	30	%	40	%
McKesson Corporation	14	%	19	%
Cardinal Health, Inc.	10	%	12	%