CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
Revenues:
Product sales, net	$ 13,708	$ 11,022
License fee and other collaboration revenues	1,753	2,327
Royalties	19	36
Total revenues	15,480	13,385
Costs and expenses:
Cost of product sales	2,646	3,041
Research and development expenses	12,462	13,566
Selling, general and administrative expenses	13,181	19,634
Total costs and expenses	28,289	36,241
Other income (expense):
Interest and dividend income, net	393	560
Gains on investments, net		1
Total other income (expense)	393	561
Net loss	$ (12,416)	$ (22,295)
Net loss per share:
Basic and diluted (in dollars per share)	$ (0.58)	$ (1.05)
Weighted average shares outstanding used to compute net loss per share:
Basic (in shares)	21,349	21,144
Diluted (in shares)	21,349	21,144