Equity-Based Compensation (Details 2) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Equity-based compensation expense
Total equity-based compensation expense	$ 8,004	$ 7,024	$ 10,038
Cost of product sales
Equity-based compensation expense
Total equity-based compensation expense	121	225	616
Research and development
Equity-based compensation expense
Total equity-based compensation expense	2,149	1,994	1,874
Selling, general and administrative
Equity-based compensation expense
Total equity-based compensation expense	$ 5,734	$ 4,805	$ 7,548