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Equity-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2013
Equity-Based Compensation  
Schedule of equity-based compensation expense

Equity-based compensation expense for 2013, 2012 and 2011 consisted of the following (in thousands):

 
   Years Ended December 31,  
 
   2013   2012   2011  

Cost of product sales

   $ 121   $ 225   $ 616  

Research and development

     2,149     1,994     1,874  

Selling, general and administrative

     5,734     4,805     7,548  
               
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​

Total equity-based compensation expense

   $ 8,004   $ 7,024   $ 10,038  
               
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
               
Summary of weighted average assumptions used for valuing option awards granted

The following table summarizes the weighted average assumptions we utilized for purposes of valuing grants of options to our employees and non-employee directors:

 
   Years Ended December 31,  
 
   2013   2012   2011  
 
   Employees   Non-Employee
Directors		   Employees   Non-Employee
Directors		   Employees   Non-Employee
Directors		  

Risk free interest rate (%)

     0.95     0.85     0.66     0.68     1.67     1.36  

Expected volatility (%)

     59     46     57     56     51     51  

Expected option term (years)

     5.00     4.00     4.66     4.00     5.50     4.00  

Dividend yield

     none     none     none     none     none     none  
Summary of details regarding stock options granted under equity incentive plans

The following table summarizes details regarding stock options granted under our equity incentive plans for the year ended December 31, 2013:

 
   December 31, 2013  
 
   Options   Weighted Average
Exercise Price		   Weighted
Average
Remaining
Contractual
Term		   Aggregate Intrinsic
Value ($ in
millions)		  

Outstanding at beginning of year

     2,190,073   $ 23.07              

Granted

     1,120,050     18.73              

Exercised

     (123,658 )   15.02              

Expired and/or forfeited

     (366,789 )   26.06              
                       
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​

Outstanding at end of year

     2,819,676   $ 21.31     7.1   $ 17.5  
                   
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
                   

Outstanding at end of year—vested and unvested expected to vest

     2,644,475   $ 21.51     7.1   $ 16.4  
                   
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
                   

Exercisable at end of year

     1,003,804   $ 28.75     5.2   $ 4.0  
                   
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
                   
Summary of details regarding restricted stock units granted under equity incentive plans

The following table summarizes details regarding restricted stock units granted under our equity incentive plans for the year ended December 31, 2013:

 
   December 31, 2013  
 
   Unvested
Restricted
Stock Units		   Weighted Average
Grant Date
Fair Value		  

Outstanding at beginning of year

     373,676   $ 17.02  

Granted

     270,525     16.31  

Vested

     (152,889 )   18.44  

Forfeited

     (25,918 )   20.77  
           
​ ​ ​ ​ ​ ​ ​ ​

Outstanding at end of year

     465,394   $ 17.28  
           
​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​
           

Outstanding at end of year and expected to vest

     382,897   $ 17.26  
           
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