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Summary of Significant Accounting Policies (Details 5) (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended 12 Months Ended
Dec. 31, 2012
Sep. 30, 2012
Jun. 30, 2012
Mar. 31, 2012
Dec. 31, 2011
Sep. 30, 2011
Jun. 30, 2011
Mar. 31, 2011
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Summary of Significant Accounting Policies                      
Net loss $ (3,686) $ (3,967) $ 3,319 $ (12,416) $ (18,581) $ (16,631) $ (19,562) $ (22,295) $ (16,750) $ (77,069) $ (81,153)
Weighted average common shares outstanding                 21,392 21,189 20,806
Net loss per share:                      
Basic and diluted (in dollars per share)         $ (0.87) $ (0.78) $ (0.92) $ (1.05) $ (0.78) $ (3.64) $ (3.90)
Anti-dilutive securities excluded from the computation of diluted net income (loss) per share                      
Anti-dilutive securities (in shares)                 2,564 2,486 2,796
Options to purchase shares of common stock
                     
Anti-dilutive securities excluded from the computation of diluted net income (loss) per share                      
Anti-dilutive securities (in shares)                 2,190 1,817 2,411
Shares of common stock issuable upon the vesting of restricted stock units
                     
Anti-dilutive securities excluded from the computation of diluted net income (loss) per share                      
Anti-dilutive securities (in shares)                 374 669 385