Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenues:
U.S. product sales, net	$ 58,287	$ 52,097	$ 59,339
International product sales and royalties	120
License fee and other collaboration revenues	26,475	8,321	6,132
Other product sales and royalties	496	831	774
Total revenues	85,378	61,249	66,245
Costs and expenses:
Cost of product sales	14,220	10,531	7,606
Research and development expenses	33,296	58,140	54,462
Selling, general and administrative expenses	53,071	68,863	84,939
Restructuring expenses	2,215	3,508	2,224
Total costs and expenses	102,802	141,042	149,231
Other income (expense):
Interest and dividend income, net	1,286	1,747	1,741
(Losses) gains on investments, net	(1,466)	(193)	408
Fair value adjustment of settlement rights			(788)
Total other income (expense)	(180)	1,554	1,361
Net loss before income taxes	(17,604)	(78,239)	(81,625)
Income tax benefit	854	1,170	472
Net loss	$ (16,750)	$ (77,069)	$ (81,153)
Net loss per share:
Basic and diluted (in dollars per share)	$ (0.78)	$ (3.64)	$ (3.90)
Weighted average shares outstanding used to compute net loss per share:
Basic and diluted (in shares)	21,392	21,189	20,806