Consolidated Quarterly Financial Data-Unaudited (Tables)

12 Months Ended

Dec. 31, 2012

Consolidated Quarterly Financial Data-Unaudited

Schedule of unaudited consolidated quarterly financial data

The following tables provide unaudited consolidated quarterly financial data for the years ended December 31, 2012 and 2011 (in thousands, except per share data):

	March 31, 2012			June 30, 2012			September 30, 2012			December 31, 2012
U.S. product sales, net(a)	$	13,626		$	14,094		$	16,186		$	14,381
International product sales and royalties		—			168			(168	)		120
License fee and other collaboration revenues(b)		1,753			16,592			1,566			6,564
Other product sales and royalties		101			158			158			79
Total revenues		15,480			31,012			17,742			21,144
Cost of product sales		2,646			3,224			4,323			4,027
Operating expenses		25,643			22,772			17,420			20,532
Restructuring expenses(c)		—			1,058			562			595
Interest and dividend income, net		393			338			295			260
(Losses) gains on investments, net(d)		—			(1,471	)		2			3
Income tax benefit		—			494			299			61
Net income (loss)	$	(12,416	)	$	3,319		$	(3,967	)	$	(3,686	)
Net income (loss) per share—basic	$	(0.58	)	$	0.16		$	(0.19	)	$	(0.17	)
Net income (loss) per share—diluted	$	(0.58	)	$	0.15		$	(0.19	)	$	(0.17	)

	March 31, 2011			June 30, 2011			September 30, 2011			December 31, 2011
U.S. product sales, net(a)	$	10,861		$	12,846		$	15,560		$	12,830
License fee and other collaboration revenues		2,327			2,288			1,707			1,999
Other product sales and royalties		197			268			288			78
Total revenues		13,385			15,402			17,555			14,907
Cost of product sales		3,041			2,082			2,669			2,739
Operating expenses		33,200			33,521			32,124			28,158
Restructuring expenses(c)		—			—			—			3,508
Interest and dividend income, net		560			452			378			357
Gains (losses) on investments, net		1			(209	)		14			1
Income tax benefit		—			396			215			559
Net loss	$	(22,295	)	$	(19,562	)	$	(16,631	)	$	(18,581	)
Net loss per share—basic and diluted	$	(1.05	)	$	(0.92	)	$	(0.78	)	$	(0.87	)