Equity-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2012

Equity-Based Compensation

Equity-based compensation expense, excluding amounts that have been capitalized into inventory

Equity-based compensation expense, excluding amounts that have been capitalized into inventory, for the years ended December 31, 2012, 2011 and 2010 consisted of the following (in thousands):

	Years Ended December 31,
	2012		2011		2010
Cost of product sales	$	225	$	616	$	441
Research and development		1,994		1,874		3,508
Selling, general and administrative		4,805		7,548		10,574
Total equity-based compensation expense	$	7,024	$	10,038	$	14,523

Equity compensation plans

Summary of weighted average assumptions used for valuing awards granted

	Years Ended December 31,
	2012				2011				2010
	Employees		Non-Employee Directors		Employees		Non-Employee Directors		Employees		Non-Employee Directors
Risk free interest rate (%)		0.66		0.68		1.67		1.36		2.47		1.61
Expected volatility (%)		57		56		51		51		58		53
Expected option term (years)		4.66		4.00		5.50		4.00		5.50		4.00
Dividend yield		none		none		none		none		none		none

Summary of details regarding stock option plans and any grants outside of the plans under an inducement grant

	December 31, 2012
	Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term		Aggregate Intrinsic Value ($ in millions)
Outstanding at beginning of year		1,817,027		$	35.16
Granted		1,500,800			14.72
Exercised		(9,188	)		10.65
Expired and/or forfeited		(1,118,566	)		31.60
Outstanding at end of year		2,190,073		$	23.07		6.7	$	0.6
Outstanding at end of year—vested and unvested expected to vest		1,981,028		$	23.82		6.7	$	0.6
Exercisable at end of year		729,294		$	36.59		6.0	$	0.1

Summary of details regarding restricted stock units granted under equity incentive plans

	December 31, 2012
	Unvested Restricted Stock Units			Weighted Average Grant Date Fair Value
Outstanding at beginning of year		669,009		$	21.16
Granted		247,050			15.64
Vested		(171,182	)		20.59
Forfeited		(371,201	)		21.91
Outstanding at end of year		373,676		$	17.02
Outstanding at end of year and expected to vest		295,916		$	16.54

Employee Stock Purchase Plans

Equity compensation plans

Summary of weighted average assumptions used for valuing awards granted

	Years Ended December 31,
	2012		2011		2010
Risk free interest rate (%)		0.12		0.09		0.22
Expected volatility (%)		43		37		42
Expected option term (years)		0.5		0.5		0.5
Dividend yield		none		none		none