Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Revenues:
Product sales, net	$ 52,813	$ 59,978	$ 16,482
License fee and other collaboration revenues	8,321	6,132	516
Royalties	115	135	180
Total revenues	61,249	66,245	17,178
Costs and expenses:
Cost of product sales	10,531	7,606	1,013
Research and development expenses	58,140	54,462	36,273
Selling, general and administrative expenses	68,863	84,939	77,829
Restructuring expenses	3,508	2,224
Total costs and expenses	141,042	149,231	115,115
Other income (expense):
Interest and dividend income, net	1,747	1,741	3,154
(Losses) gains on investments, net	(193)	408	942
Fair value adjustment of settlement rights		(788)	(778)
Total other income (expense)	1,554	1,361	3,318
Net loss before income taxes	(78,239)	(81,625)	(94,619)
Income tax benefit	1,170	472	1,268
Net loss	$ (77,069)	$ (81,153)	$ (93,351)
Net loss per share:
Basic and diluted (in dollars per share)	$ (3.64)	$ (3.90)	$ (5.46)
Weighted average shares outstanding used to compute net loss per share:
Basic (in shares)	21,189	20,806	17,109
Diluted (in shares)	21,189	20,806	17,109