CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Revenues:
Revenues	$ 93,106	$ 83,808	$ 210,637	$ 237,062
Costs and expenses:
Cost of product sales	$ 13,340	$ 21,105	$ 55,426	$ 63,871
Cost, Product and Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Research and development expenses	$ 7,115	$ 15,330	$ 26,558	$ 48,377
Acquired in-process research and development	0	0	0	74,856
Selling, general and administrative expenses	35,656	65,720	127,922	217,727
Impairment of intangible assets	0	0	0	77,358
Loss on disposal of assets, net	35,400	0	20,956	0
Restructuring expenses	0	0	8,197	7,420
Total costs and expenses	91,511	102,155	239,059	489,609
Operating income (loss)	1,595	(18,347)	(28,422)	(252,547)
Other income (expense):
Interest expense	(6,798)	(6,419)	(20,101)	(19,199)
Interest and dividend income	246	840	1,050	3,650
Other income	14,606	218	15,894	561
Total other income (expense), net	8,054	(5,361)	(3,157)	(14,988)
Income (loss) before income taxes	9,649	(23,708)	(31,579)	(267,535)
Income tax (benefit) expense	(53)	232	(113)	(26)
Net income (loss)	$ 9,702	$ (23,940)	$ (31,466)	$ (267,509)
Net income (loss) per share:
Basic (in dollars per share)	$ 0.28	$ (0.71)	$ (0.92)	$ (7.85)
Diluted (in dollars per share)	$ 0.28	$ (0.71)	$ (0.92)	$ (7.85)
Weighted average shares outstanding used to compute net income (loss) per share:
Basic (in shares)	34,484	33,906	34,314	34,058
Diluted (in shares)	34,720	33,906	34,314	34,058
Product Sales
Revenues:
Revenues	$ 73,229	$ 83,784	$ 190,702	$ 236,831
Collaboration revenue
Revenues:
Revenues	19,838	0	19,838	0
Other revenues
Revenues:
Revenues	$ 39	$ 24	$ 97	$ 231