CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Revenues:
Revenues	$ 52,755	$ 77,767	$ 123,200	$ 153,255
Costs and expenses:
Cost of product sales	$ 18,180	$ 24,290	$ 42,539	$ 42,767
Cost, Product and Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Research and development expenses	$ 8,263	$ 14,980	$ 19,443	$ 33,046
Acquired in-process research and development	0	0	0	74,856
Selling, general and administrative expenses	39,568	77,324	92,266	152,006
Impairment of intangible assets	0	77,358	0	77,358
Gain on sale of assets	(14,444)	0	(14,444)	0
Restructuring expenses	8,197	0	8,197	7,420
Total costs and expenses	59,764	193,952	148,001	387,453
Operating loss	(7,009)	(116,185)	(24,801)	(234,198)
Other income (expense):
Interest expense	(6,700)	(6,330)	(13,303)	(12,780)
Interest and dividend income	327	1,224	804	2,810
Other income (expense)	(22)	2	1,288	342
Total other expense, net	(6,395)	(5,104)	(11,211)	(9,628)
Loss before income taxes	(13,404)	(121,289)	(36,012)	(243,826)
Income tax benefit	(160)	(120)	(60)	(257)
Net loss	$ (13,244)	$ (121,169)	$ (35,952)	$ (243,569)
Basic and diluted net loss per share (in dollars per share)	$ (0.39)	$ (3.58)	$ (1.05)	$ (7.14)
Weighted average shares outstanding used to compute net loss per share (basic and diluted) (in shares)	34,353	33,807	34,228	34,136
Product Sales
Revenues:
Revenues	$ 52,729	$ 77,634	$ 123,142	$ 153,047
Other revenues
Revenues:
Revenues	$ 26	$ 133	$ 58	$ 208