CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Cash flows from operating activities:
Net loss	$ (24,491)	$ (122,084)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Depreciation and amortization	10,318	4,375
Provision for bad debt expense	223	(16)
Amortization of premium/discount on purchased securities	4	(27)
Write-down of inventory	616	0
Non-cash equity-based compensation expense	3,868	4,873
Non-cash IPR&D expense	0	18,029
Amortization of debt discount and debt issuance costs	4,004	3,783
Gains on marketable securities, net	(9)	0
Change in fair value of contingent consideration	0	(6)
Deferred income taxes	630	458
Non-cash lease expense	451	0
Gain on sale of assets	(1,409)	0
Changes in operating assets and liabilities:
Accounts receivable, net	(12,547)	(7,971)
Inventories	(2,770)	(2,973)
Prepaid and other current assets	(6,490)	(21,580)
Accounts payable and accrued expenses	(19,671)	31,432
Other assets and liabilities	664	1,799
Net cash used in operating activities	(46,609)	(89,908)
Cash flows from investing activities:
Proceeds from sales or maturities of marketable securities	11,255	27,945
Purchase of marketable securities	(23,345)	(14,815)
Net proceeds from the sale of assets	1,440	0
Capital expenditures	(68)	(1,794)
Net cash (used in) provided by investing activities	(10,718)	11,336
Cash flows from financing activities:
Payments to settle convertible notes	0	(21,417)
Payments of contingent consideration	(17)	(17)
Payments for repurchases of common stock	0	(13,730)
Proceeds from the exercise of common stock options	0	33
Payments of employee tax withholding related to equity-based compensation	(1,210)	(1,636)
Net cash used in financing activities	(1,227)	(36,767)
Net decrease in cash, cash equivalents, and restricted cash	(58,554)	(115,339)
Cash, cash equivalents, and restricted cash at beginning of the period	113,504	253,751
Cash, cash equivalents, and restricted cash at end of the period	54,950	138,412
Supplemental data for cash flow information:
Cash (refunded) paid for taxes	(256)	78
Cash paid for interest	0	267
Non-cash investing and financing activities:
Settlement of note receivable in connection with Perosphere acquisition	0	10,000
Right-of-use assets obtained in exchange for lease liabilities	$ 0	$ 918