Equity-Based Compensation - Equity-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended			9 Months Ended
	Sep. 30, 2019	Mar. 31, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Equity-based compensation expense
Total equity-based compensation expense	$ 4,974		$ 5,051	$ 13,716	$ 14,633
Income tax effect	0		0	0	0
After-tax effect of equity-based compensation expense	4,974		5,051	13,716	14,633
Cost of product sales
Equity-based compensation expense
Total equity-based compensation expense	225		281	626	588
Research and development
Equity-based compensation expense
Total equity-based compensation expense	691		568	2,051	1,896
Selling, general and administrative
Equity-based compensation expense
Total equity-based compensation expense	$ 4,058		$ 4,202	$ 11,039	$ 12,149
Restructuring Charges
Equity-based compensation expense
Total equity-based compensation expense		$ 700