CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Cash flows from operating activities:
Net loss	$ (266,528)	$ (43,484)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Depreciation and amortization	13,871	158,002
Impairment of intangible assets	77,358	0
Provision for bad debt expense	(12)	754
Amortization of premium/discount on purchased securities	(64)	96
Write-down of inventory	4,872	0
Gain on disposal of fixed assets	0	(99)
Non-cash equity-based compensation expense	14,381	14,599
Non-cash IPR&D expense	18,029	0
Loss on debt extinguishment	0	35,922
Amortization of debt discount and debt issuance costs	11,332	11,824
Gains on marketable securities, net	(263)	(1)
Change in fair value of contingent consideration	(16)	(49,175)
Deferred income taxes	408	43,747
Gain on sale of the CBR business	0	(89,581)
Transaction costs	0	(14,111)
Changes in operating assets and liabilities:
Accounts receivable, net	(2,229)	7,175
Inventories	(6,824)	3,587
Prepaid and other current assets	(24,075)	1,101
Accounts payable and accrued expenses	53,092	(4,280)
Deferred revenues	(101)	8,658
Other assets and liabilities	1,038	159
Net cash (used in) provided by operating activities	(105,731)	84,893
Cash flows from investing activities:
Proceeds from sales or maturities of marketable securities	85,321	60,146
Purchase of marketable securities	(14,815)	(64,400)
Purchase of developed technology	(60,000)	0
Proceeds from the sale of the CBR business	0	519,303
Capital expenditures	(2,098)	(1,913)
Net cash provided by investing activities	8,408	513,136
Cash flows from financing activities:
Long-term debt principal payments	0	(475,000)
Payments to settle convertible notes	(21,417)	0
Payment of premium on debt extinguishment	0	(28,054)
Payments of contingent consideration	(50)	(87)
Payments for repurchases of common stock	(13,730)	0
Proceeds from the issuance of common stock under the ESPP	851	0
Proceeds from the exercise of common stock options	30	2,635
Payments of employee tax withholding related to equity-based compensation	(1,817)	(2,632)
Net cash used in financing activities	(36,133)	(503,138)
Net (decrease) increase in cash, cash equivalents, and restricted cash	(133,456)	94,891
Cash, cash equivalents, and restricted cash at beginning of the period	253,751	192,770
Cash, cash equivalents, and restricted cash at end of the period	120,295	287,661
Supplemental data for cash flow information:
Cash paid for taxes	456	5,041
Cash paid for interest	5,467	43,546
Non-cash investing and financing activities:
Settlement of note receivable in connection with Perosphere acquisition	$ 10,000	$ 0