Equity-Based Compensation - Equity-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended			6 Months Ended
	Jun. 30, 2019	Mar. 31, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Equity-based compensation expense
Total equity-based compensation expense	$ 4,534		$ 4,792	$ 8,742	$ 9,583
Income tax effect	0		835	0	0
After-tax effect of equity-based compensation expense	4,534		5,627	8,742	9,583
Cost of product sales
Equity-based compensation expense
Total equity-based compensation expense	198		107	401	307
Research and development
Equity-based compensation expense
Total equity-based compensation expense	680		608	1,360	1,328
Selling, general and administrative
Equity-based compensation expense
Total equity-based compensation expense	$ 3,656		$ 4,077	$ 6,981	$ 7,948
Restructuring Charges
Equity-based compensation expense
Total equity-based compensation expense		$ 700