Equity-Based Compensation - Equity-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Equity-based compensation expense
Total equity-based compensation expense	$ 4,207	$ 4,790
Income tax effect	0	(835)
After-tax effect of equity-based compensation expense	4,207	3,955
Cost of product sales
Equity-based compensation expense
Total equity-based compensation expense	202	200
Research and development
Equity-based compensation expense
Total equity-based compensation expense	680	720
Selling, general and administrative
Equity-based compensation expense
Total equity-based compensation expense	3,325	$ 3,870
Restructuring Charges
Equity-based compensation expense
Total equity-based compensation expense	$ 700