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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Statement of Cash Flows [Abstract]    
Net loss $ (122,084) $ (54,242)
Adjustments to reconcile net loss to net cash provided by operating activities:    
Depreciation and amortization 4,375 59,485
Provision for bad debt expense (16) 463
Amortization of premium/discount on purchased securities (27) 67
Non-cash equity-based compensation expense 4,873 5,533
Non-cash IPR&D expense 18,029 0
Amortization of debt discount and debt issuance costs 3,783 3,880
Change in fair value of contingent consideration (6) 626
Deferred income taxes 458 (6,643)
Changes in operating assets and liabilities:    
Accounts receivable, net (7,971) 3,093
Inventories (2,973) 3,534
Prepaid and other current assets (21,580) (3,720)
Accounts payable and accrued expenses 31,432 30,374
Deferred revenues 0 3,027
Other assets and liabilities 1,799 215
Net cash (used in) provided by operating activities (89,908) 45,692
Cash flows from investing activities:    
Proceeds from sales or maturities of marketable securities 27,945 18,225
Purchase of marketable securities (14,815) (21,102)
Capital expenditures (1,794) (923)
Net cash provided by (used in) investing activities 11,336 (3,800)
Cash flows from financing activities:    
Payments to settle convertible notes (21,417) 0
Payments of contingent consideration (17) (44)
Payments for repurchases of common stock (13,730) 0
Proceeds from the exercise of common stock options 33 123
Payments of employee tax withholding related to equity-based compensation (1,636) (2,348)
Net cash used in financing activities (36,767) (2,269)
Net (decrease) increase in cash, cash equivalents, and restricted cash (115,339) 39,623
Cash, cash equivalents, and restricted cash at beginning of the period 253,751 192,770
Cash, cash equivalents, and restricted cash at end of the period 138,412 232,393
Supplemental data for cash flow information:    
Cash paid for taxes 78 136
Cash paid for interest 267 18,971
Non-cash investing and financing activities:    
Settlement of note receivable in connection with Perosphere acquisition $ 10,000 $ 0