Income Taxes - Narrative (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2018 USD ($) state_audit ownership_change	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)
Tax Credit Carryforward [Line Items]
Income tax expense (benefit)	$ 39,654	$ (175,254)	$ 13,171
Effective tax rate	(30.60%)	46.10%	86.30%
Statutory U.S. federal tax rate	21.00%	35.00%	35.00%
Tax cuts and jobs act, provisional tax benefit		$ 17,600
Increase in valuation allowance	$ 108,500
Increase (decrease) in unrecognized tax benefits	$ 600	$ (2,500)	$ 300
Number of state audits in progress | state_audit	2
Lumara Health Inc.
Tax Credit Carryforward [Line Items]
Number of ownership changes | ownership_change	2
Domestic Tax Authority
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	$ 199,000
Tax credit carryforward, amount	23,400
Domestic Tax Authority | Lumara Health Inc.
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	123,100
Tax credit carryforward, amount	2,300
State and Local Jurisdiction
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	92,900
Tax credit carryforward, amount	1,200
State and Local Jurisdiction | Lumara Health Inc.
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	16,600
Capital Loss Carryforward | Discontinued Operations, Held-for-sale or Disposed of by Sale | CBR business
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	90,500
Interest Expense Carryforward
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	$ 17,800