Description of Business (Details) $ in Thousands		12 Months Ended
	Aug. 06, 2018 USD ($)	Dec. 31, 2018 USD ($) product_candidate	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of product candidates | product_candidate		3
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Gain on sale of CBR business		$ 87,076	$ 0	$ 0
CBR business | Discontinued Operations, Held-for-sale or Disposed of by Sale
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Cash consideration for sale of wholly-owned subsidiary	$ 519,300
Gain on sale of CBR business	$ 87,100	$ 87,076	$ 0	$ 0