CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues:
Revenues	$ 474,002	$ 495,769	$ 432,487
Costs and expenses:
Cost of product sales	215,892	161,349	96,314
Research and development expenses	44,846	75,017	65,561
Acquired in-process research and development	32,500	65,845	0
Selling, general and administrative expenses	227,810	178,151	169,468
Impairment of intangible assets	0	319,246	15,724
Restructuring expenses	0	0	341
Total costs and expenses	521,048	799,608	347,408
Operating (loss) income	(47,046)	(303,839)	85,079
Other income (expense):
Interest expense	(51,971)	(68,382)	(73,153)
Loss on debt extinguishment	(35,922)	(10,926)	0
Interest and dividend income	5,328	2,810	3,149
Other (expense) income	(74)	(70)	189
Total other expense, net	(82,639)	(76,568)	(69,815)
(Loss) income from continuing operations before income taxes	(129,685)	(380,407)	15,264
Income tax expense (benefit)	39,654	(175,254)	13,171
Net (loss) income from continuing operations	(169,339)	(205,153)	2,093
Discontinued operations:
Income (loss) from discontinued operations	18,873	10,313	(6,209)
Gain on sale of CBR business	87,076	0	0
Income tax expense (benefit)	2,371	4,388	(1,633)
Net income (loss) from discontinued operations	103,578	5,925	(4,576)
Net loss	$ (65,761)	$ (199,228)	$ (2,483)
Basic net (loss) income per share:
(Loss) income from continuing operations (in dollars per share)	$ (4.92)	$ (5.88)	$ 0.06
Income (loss) from discontinued operations (in dollars per share)	3.01	0.17	(0.13)
Total (in dollars per share)	(1.91)	(5.71)	(0.07)
Diluted net (loss) income per share:
(Loss) income from continuing operations (in dollars per share)	(4.92)	(5.88)	0.06
Income (loss) from discontinued operations (in dollars per share)	3.01	0.17	(0.13)
Total (in dollars per share)	$ (1.91)	$ (5.71)	$ (0.07)
Weighted average shares outstanding used to compute net (loss) income per share:
Basic (in shares)	34,394	34,907	34,346
Diluted (in shares)	34,394	34,907	34,833
Product
Revenues:
Revenues	$ 473,852	$ 495,645	$ 432,170
Product and Service, Other
Revenues:
Revenues	$ 150	$ 124	$ 317