CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017
Statement of Cash Flows [Abstract]
Net loss	$ (43,484)	$ (202,688)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	158,002	88,941
Impairment charges of intangible assets	0	319,246
Provision for bad debt expense	754	3,503
Amortization of premium/discount on purchased securities	96	218
Gain on disposal of fixed assets	(99)	0
Non-cash equity-based compensation expense	14,599	18,058
Non-cash IPR&D expense	0	945
Loss on debt extinguishment	35,922	9,830
Amortization of debt discount and debt issuance costs	11,824	10,600
Gains on marketable securities, net	(1)	(255)
Change in fair value of contingent consideration	(49,175)	(47,142)
Deferred income taxes	43,747	(146,682)
Gain on sale of the CBR business	(89,581)	0
Transaction costs	(14,111)	0
Changes in operating assets and liabilities:
Accounts receivable, net	7,175	(8,889)
Inventories	3,587	(600)
Prepaid and other current assets	1,101	(1,409)
Accounts payable and accrued expenses	(4,280)	29,977
Deferred revenues	8,658	14,134
Other assets and liabilities	159	(1,139)
Net cash provided by operating activities	84,893	86,648
Cash flows from investing activities:
Proceeds from sales or maturities of marketable securities	60,146	279,526
Purchase of marketable securities	(64,400)	(110,894)
Acquisition of Intrarosa intangible asset	0	(55,800)
Proceeds from the sale of the CBR business	519,303	0
Capital expenditures	(1,913)	(6,573)
Net cash provided by investing activities	513,136	106,259
Cash flows from financing activities:
Long-term debt principal payments	(475,000)	(328,125)
Proceeds from 2022 Convertible Notes	0	320,000
Payment to repurchase 2019 Convertible Notes	0	(191,480)
Payment of premium on debt extinguishment	(28,054)	0
Proceeds to settle warrants	0	323
Payment of convertible debt issuance costs	0	(9,553)
Payments of contingent consideration	(87)	(165)
Proceeds from the exercise of common stock options	2,635	2,350
Payments of employee tax withholding related to equity-based compensation	(2,632)	(2,588)
Net cash used in financing activities	(503,138)	(209,238)
Net increase (decrease) in cash, cash equivalents, and restricted cash	94,891	(16,331)
Cash, cash equivalents, and restricted cash related to discontinued operations	0	(50,017)
Cash, cash equivalents, and restricted cash at beginning of the period	192,770	276,898
Cash, cash equivalents, and restricted cash at end of the period	287,661	210,550
Supplemental data for cash flow information:
Cash paid for taxes	5,041	3,565
Cash paid for interest	43,546	50,892
Non-cash investing and financing activities:
Fair value of common stock issued in connection with the acquisition of the Intrarosa intangible asset	0	12,555
Contingent consideration accrued for the acquisition of the Intrarosa intangible asset	$ 0	$ 9,300