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Equity-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of details regarding stock option activity
The following table summarizes stock option activity for the nine months ended September 30, 2018:
 
2007 Equity
 
2013 Lumara
 
Inducement
 
 
 
Plan
 
Equity Plan
 
Grants
 
Total
Outstanding at December 31, 2017
2,590,373

 
125,536

 
815,450

 
3,531,359

Granted
836,846

 
35,400

 
102,393

 
974,639

Exercised
(133,547
)
 
(2,812
)
 

 
(136,359
)
Expired or terminated
(549,156
)
 
(30,675
)
 
(90,000
)
 
(669,831
)
Outstanding at September 30, 2018
2,744,516

 
127,449

 
827,843

 
3,699,808

Summary of details regarding restricted stock activity
The following table summarizes RSU activity for the nine months ended September 30, 2018:
 
2007 Equity
 
2013 Lumara
 
Inducement
 
 
 
Plan
 
Equity Plan
 
Grants
 
Total
Outstanding at December 31, 2017
966,623

 
11,611

 
91,541

 
1,069,775

Granted
752,797

 
1,600

 
48,418

 
802,815

Vested
(370,388
)
 
(10,650
)
 
(47,764
)
 
(428,802
)
Expired or terminated
(306,234
)
 
(460
)
 
(2,502
)
 
(309,196
)
Outstanding at September 30, 2018
1,042,798

 
2,101

 
89,693

 
1,134,592

Schedule of equity-based compensation expense
Equity-based compensation expense for the three and nine months ended September 30, 2018 and 2017 consisted of the following (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2018
 
2017
 
2018
 
2017
Cost of product sales
$
281

 
$
432

 
$
588

 
$
690

Research and development
568

 
799

 
1,896

 
2,651

Selling, general and administrative
4,202

 
4,410

 
12,149

 
12,037

Total equity-based compensation expense
5,051

 
5,641

 
14,633

 
15,378

Income tax effect

 
(1,674
)
 

 
(4,569
)
After-tax effect of equity-based compensation expense
$
5,051

 
$
3,967

 
$
14,633

 
$
10,809