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Equity-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of details regarding stock option activity
The following table summarizes stock option activity for the six months ended June 30, 2018:
 
2007 Equity
 
2013 Lumara
 
Inducement
 
 
 
Plan
 
Equity Plan
 
Grants
 
Total
Outstanding at December 31, 2017
2,590,373

 
125,536

 
815,450

 
3,531,359

Granted
669,212

 
35,400

 
62,393

 
767,005

Exercised
(71,631
)
 
(2,375
)
 
—

 
(74,006
)
Expired or terminated
(237,948
)
 
(19,061
)
 
(74,375
)
 
(331,384
)
Outstanding at June 30, 2018
2,950,006

 
139,500

 
803,468

 
3,892,974
Summary of details regarding restricted stock activity
The following table summarizes RSU activity for the six months ended June 30, 2018:
 
2007 Equity
 
2013 Lumara
 
Inducement
 
 
 
Plan
 
Equity Plan
 
Grants
 
Total
Outstanding at December 31, 2017
966,623

 
11,611

 
91,541

 
1,069,775

Granted
742,527

 
1,600

 
28,418

 
772,545

Vested
(319,367
)
 
(10,150
)
 
(16,265
)
 
(345,782
)
Expired or terminated
(81,093
)
 
(460
)
 
—

 
(81,553
)
Outstanding at June 30, 2018
1,308,690

 
2,601

 
103,694

 
1,414,985
Schedule of equity-based compensation expense
Equity-based compensation expense for the three and six months ended June 30, 2018 and 2017 consisted of the following (in thousands):
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2018
 
2017
 
2018
 
2017
Cost of product sales
$
107

 
$
129

 
$
307

 
$
258

Research and development
608

 
1,095

 
1,328

 
1,851

Selling, general and administrative
4,077

 
3,781

 
7,948

 
7,626

Total equity-based compensation expense
4,792

 
5,005

 
9,583

 
9,735

Income tax effect
835

 
(1,529
)
 
—

 
(2,895
)
After-tax effect of equity-based compensation expense
$
5,627

 
$
3,476

 
$
9,583

 
$
6,840