Current and Long- Term Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Payables and Accruals [Abstract]
Commercial rebates, fees and returns	$ 114,884	$ 102,357
Professional, license, and other fees and expenses	29,033	28,692
Accrued research and development	14,034	19,099
Interest expense	6,639	13,525
Bremelanotide milestone payment	20,000	0
Interest expense	10,000	10,000
Accrued research and development	4,481	1,817
Total accrued expenses	199,071	175,490
Deferred revenue	$ 69,900	$ 66,900