Property, Plant and Equipment, Net (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Property, plant and equipment, net
Property, plant and equipment, gross	$ 46,407	$ 45,486
Less: accumulated depreciation	(20,486)	(19,490)
Property, plant and equipment, net	25,921	25,996
Land
Property, plant and equipment, net
Property, plant and equipment, gross	700	700
Land improvements
Property, plant and equipment, net
Property, plant and equipment, gross	300	300
Building and improvements
Property, plant and equipment, net
Property, plant and equipment, gross	9,552	9,552
Computer equipment and software
Property, plant and equipment, net
Property, plant and equipment, gross	14,072	14,073
Furniture and fixtures
Property, plant and equipment, net
Property, plant and equipment, gross	2,513	2,512
Leasehold improvements
Property, plant and equipment, net
Property, plant and equipment, gross	4,959	4,959
Laboratory and production equipment
Property, plant and equipment, net
Property, plant and equipment, gross	13,286	8,030
Construction in progress
Property, plant and equipment, net
Property, plant and equipment, gross	$ 1,025	$ 5,360