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Fair Value Measurements - Contingent Consideration (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]      
Contingent consideration accrued $ 199,071   $ 175,490
Acquired in-process research and development 20,000 $ 60,000  
Reconciliation of contingent consideration obligations related to acquisitions      
Current portion of acquisition-related contingent consideration 50,007   $ 49,399
Makena      
Reconciliation of contingent consideration obligations related to acquisitions      
Current portion of acquisition-related contingent consideration 49,800    
MuGard      
Reconciliation of contingent consideration obligations related to acquisitions      
Current portion of acquisition-related contingent consideration 200    
Estimated undiscounted royalty amounts payable, maximum $ 6,000    
Discount rate 14.00%    
Estimated undiscounted royalty amounts payable, minimum $ 2,000    
Period over which estimated undiscounted royalty amounts could be paid 10 years    
Contingent Consideration      
Reconciliation of contingent consideration obligations related to acquisitions      
Balance at beginning of period $ 50,085    
Payments made (44)    
Adjustments to fair value of contingent consideration 626    
Balance at end of period 50,667    
Contingent Consideration | Endoceutics License Agreement      
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]      
Contingent consideration accrued $ 10,000