Equity-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2018

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of details regarding stock option activity

The following table summarizes stock option activity for the three months ended March 31, 2018:

	2007 Equity		2013 Lumara		Inducement
	Plan		Equity Plan		Grants		Total
Outstanding at December 31, 2017	2,590,373		125,536		815,450		3,531,359
Granted	451,411		—		—		451,411
Exercised	(7,782	)	—		—		(7,782	)
Expired or terminated	(160,797	)	(15,436	)	(27,875	)	(204,108	)
Outstanding at March 31, 2018	2,873,205		110,100		787,575		3,770,880

Summary of details regarding restricted stock activity

The following table summarizes RSU activity for the three months ended March 31, 2018:

	2007 Equity		2013 Lumara		Inducement
	Plan		Equity Plan		Grants		Total
Outstanding at December 31, 2017	966,623		11,611		91,541		1,069,775
Granted	712,781		—		—		712,781
Vested	(317,638	)	(10,150	)	(15,666	)	(343,454	)
Expired or terminated	(38,078	)	(460	)	—		(38,538	)
Outstanding at March 31, 2018	1,323,688		1,001		75,875		1,400,564

Schedule of equity-based compensation expense

Equity-based compensation expense for the three months ended March 31, 2018 and 2017 consisted of the following (in thousands):

	Three Months Ended March 31,
	2018			2017
Cost of product sales and services	$	347		$	129
Research and development	720			756
Selling, general and administrative	4,466			4,893
Total equity-based compensation expense	5,533			5,778
Income tax effect	(942		)	(1,605		)
After-tax effect of equity-based compensation expense	$	4,591		$	4,173