Income Taxes - Deferred Tax Components (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Assets
Net operating loss carryforwards	$ 61,070	$ 116,275
Tax credit carryforwards	15,892	9,415
Deferred revenue	3,420	1,811
Equity-based compensation expense	6,401	8,045
Capitalized research & development	7,872	18,284
Reserves	4,273	8,018
Contingent consideration	1,406	4,140
Other	6,777	9,769
Valuation allowance	(5,597)	(1,429)
Liabilities
Property, plant and equipment depreciation	(1,501)	(2,145)
Intangible assets and inventory	(107,906)	(367,667)
Debt instruments	(15,744)	(1,040)
Other	(290)	(542)
Net deferred tax liabilities	$ (23,927)	$ (197,066)