CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016
Cash flows from operating activities:
Net (loss) income	$ (202,688)	$ 8,074
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	88,941	68,960
Impairment of intangible assets	319,246	15,963
Provision for bad debt expense	3,503	2,209
Amortization of premium/discount on purchased securities	218	518
Non-cash equity-based compensation expense	18,058	16,809
Non-cash IPR&D expense	945	0
Loss on debt extinguishment	9,830	0
Amortization of debt discount and debt issuance costs	10,600	9,015
(Loss) gains on investments, net	(255)	24
Change in fair value of contingent consideration	(47,142)	5,106
Deferred income taxes	(146,682)	2,573
Changes in operating assets and liabilities:
Accounts receivable, net	(8,889)	13,390
Inventories	(600)	(1,369)
Receivable from collaboration	0	428
Prepaid and other current assets	(1,409)	(1,293)
Accounts payable and accrued expenses	29,977	19,940
Deferred revenues	14,134	21,888
Other assets and liabilities	(1,139)	1,467
Net cash provided by operating activities	86,648	183,702
Cash flows from investing activities:
Proceeds from sales or maturities of investments	279,526	71,733
Purchase of investments	(110,894)	(142,175)
Intrarosa developed technology	(55,800)	0
Change in restricted cash	(60)	0
Capital expenditures	(6,573)	(3,360)
Net cash provided by (used in) investing activities	106,199	(73,802)
Cash flows from financing activities:
Long-term debt principal payments	(328,125)	(13,127)
Proceeds from 2022 Convertible Notes	320,000	0
Payment to repurchase 2019 Convertible Notes	(191,480)	0
Proceeds to settle warrants	323	0
Payment of convertible debt issuance costs	(9,553)	0
Payments of contingent consideration	(165)	(212)
Payments for repurchases of common stock	0	(20,000)
Proceeds from the issuance and exercise of common stock options	2,350	2,184
Payments of employee tax withholding related to equity-based compensation	(2,588)	(2,171)
Net cash used in financing activities	(209,238)	(33,326)
Net (decrease) increase in cash and cash equivalents	(16,391)	76,574
Cash and cash equivalents at beginning of the period	274,305	228,705
Cash and cash equivalents at end of the period	257,914	305,279
Supplemental data for cash flow information:
Cash paid for taxes	3,565	4,611
Cash paid for interest	50,892	58,319
Non-cash investing and financing activities:
Fair value of common stock issued in connection with the acquisition of the Intrarosa intangible asset	12,555	0
Contingent consideration accrued for the acquisition of the Intrarosa intangible asset	$ 9,300	$ 0