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Fair Value Measurements - Contingent Consideration (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2017
Sep. 30, 2016
Dec. 31, 2016
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]        
Contingent consideration accrued $ 190,457 $ 190,457   $ 156,008
Reconciliation of contingent consideration obligations related to acquisitions        
Adjustments to fair value of contingent consideration   (47,142) $ 5,106  
Makena        
Reconciliation of contingent consideration obligations related to acquisitions        
Adjustments to fair value of contingent consideration 50,400 49,200    
Contingent consideration classified as short-term liability 98,800 98,800    
Undiscounted milestone payment 250,000 250,000    
MuGard        
Reconciliation of contingent consideration obligations related to acquisitions        
Contingent consideration classified as short-term liability 300 300    
Undiscounted milestone payment 6,000 $ 6,000    
Discount rate   11.00%    
Estimated undiscounted royalty amounts payable 2,000 $ 2,000    
Period over which estimated undiscounted royalty amounts could be paid   10 years    
Contingent Consideration        
Reconciliation of contingent consideration obligations related to acquisitions        
Balance at beginning of period   $ 147,995    
Payments made   (165)    
Adjustments to fair value of contingent consideration   (47,142)    
Balance at end of period 100,688 100,688    
Contingent Consideration | Endoceutics License Agreement        
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]        
Contingent consideration accrued $ 10,000 $ 10,000