CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Product sales, net	$ 124,331	$ 115,777	$ 367,190	$ 308,324
Service revenues, net	29,410	27,965	84,365	71,863
License fee, collaboration and other revenues	0	40	53	313
Total revenues	153,741	143,782	451,608	380,500
Costs and expenses:
Cost of product sales	31,085	25,706	90,761	65,942
Cost of services	5,559	4,984	16,130	15,705
Research and development expenses	16,274	17,116	63,021	45,579
Acquired in-process research and development	0	0	65,845	0
Selling, general and administrative expenses	31,307	57,216	182,719	172,314
Impairment charges of intangible assets	319,246	0	319,246	15,963
Restructuring expenses	0	0	0	712
Total costs and expenses	403,471	105,022	737,722	316,215
Operating (loss) income	(249,730)	38,760	(286,114)	64,285
Other (expense) income:
Interest expense	(16,847)	(18,309)	(52,403)	(55,002)
Loss on debt extinguishment	(314)	0	(9,830)	0
Interest and dividend income	487	838	2,181	2,319
Other (expense) income	0	(24)	(43)	197
Total other (expense) income	(16,674)	(17,495)	(60,095)	(52,486)
(Loss) income before income taxes	(266,404)	21,265	(346,209)	11,799
Income tax (benefit) expense	(114,343)	5,069	(143,521)	3,725
Net (loss) income	$ (152,061)	$ 16,196	$ (202,688)	$ 8,074
Net (loss) income per share:
Basic (in usd per share)	$ (4.31)	$ 0.47	$ (5.80)	$ 0.23
Diluted (in usd per share)	$ (4.31)	$ 0.43	$ (5.80)	$ 0.23
Weighted average shares outstanding used to compute net (loss) income per share:
Basic (in shares)	35,311	34,171	34,948	34,377
Diluted (in shares)	35,311	42,111	34,948	34,764