Equity-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2017

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of details regarding stock options granted under equity incentive plans

The following table summarizes stock option activity for the nine months ended September 30, 2017:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2016	2,158,822		5,200	134,181		814,975		3,113,178
Granted	931,417		—	—		91,100		1,022,517
Exercised	(90,696	)	—	—		—		(90,696	)
Expired or terminated	(306,070	)	—	(7,969	)	(72,125	)	(386,164	)
Outstanding at September 30, 2017	2,693,473		5,200	126,212		833,950		3,658,835

Summary of details regarding restricted stock units granted under equity incentive plans

The following table summarizes RSU activity for the nine months ended September 30, 2017:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2016	773,804		—	27,694		135,456		936,954
Granted	790,476		—	—		24,300		814,776
Vested	(349,306	)	—	(12,831	)	(45,662	)	(407,799	)
Expired or terminated	(181,986	)	—	(752	)	(9,819	)	(192,557	)
Outstanding at September 30, 2017	1,032,988		—	14,111		104,275		1,151,374

Schedule of equity-based compensation expense

Equity-based compensation expense for the three and nine months ended September 30, 2017 and 2016 consisted of the following (in thousands):

	Three Months Ended September 30,						Nine Months Ended September 30,
	2017			2016			2017			2016
Cost of product sales and services	$	566		$	118		$	892		$	395
Research and development	799			858			2,651			2,583
Selling, general and administrative	5,024			4,492			14,515			13,831
Total equity-based compensation expense	6,389			5,468			18,058			16,809
Income tax effect	(1,805		)	(1,568		)	(5,127		)	(4,637		)
After-tax effect of equity-based compensation expense	$	4,584		$	3,900		$	12,931		$	12,172