CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Cash flows from operating activities:
Net loss	$ (50,626)	$ (8,123)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	59,563	41,231
Impairment of intangible assets	0	15,963
Provision for bad debt expense	2,681	0
Amortization of premium/discount on purchased securities	168	351
Non-cash equity-based compensation expense	11,669	11,342
Non-cash IPR&D expense	945	0
Loss on debt extinguishment	9,516	0
Amortization of debt discount and debt issuance costs	6,679	5,940
Gains on investments, net	(249)	0
Change in fair value of contingent consideration	2,786	1,399
Deferred income taxes	(29,677)	(1,371)
Changes in operating assets and liabilities:
Accounts receivable, net	233	19,592
Inventories	(1,145)	281
Receivable from collaboration	0	428
Prepaid and other current assets	(1,178)	(273)
Accounts payable and accrued expenses	40,716	4,700
Deferred revenues	7,380	17,204
Other assets and liabilities	(1,029)	1,970
Net cash provided by operating activities	58,432	110,634
Cash flows from investing activities:
Proceeds from sales or maturities of investments	251,017	42,500
Purchase of investments	(85,249)	(98,795)
Acquisition of Intrarosa intangible asset	(46,500)	0
Change in restricted cash	(60)	0
Capital expenditures	(2,672)	(2,587)
Net cash provided by (used in) investing activities	116,536	(58,882)
Cash flows from financing activities:
Long-term debt principal payments	(328,125)	(8,752)
Proceeds from 2022 Convertible Notes	320,000	0
Payment to extinguish 2019 Convertible Notes	(170,371)	0
Proceeds to settle warrants	323	0
Payment of convertible debt issuance costs	(9,553)	0
Payments of contingent consideration	(119)	(149)
Payments for repurchases of common stock	0	(20,000)
Proceeds from the issuance and exercise of common stock options	1,130	1,569
Payments of employee tax withholding related to equity-based compensation	(2,439)	(2,015)
Net cash used in financing activities	(189,154)	(29,347)
Net (decrease) increase in cash and cash equivalents	(14,186)	22,405
Cash and cash equivalents at beginning of the period	274,305	228,705
Cash and cash equivalents at end of the period	260,119	251,110
Supplemental data for cash flow information:
Cash paid for taxes	3,191	3,903
Cash paid for interest	29,173	32,017
Non-cash investing activities:
Fair value of common stock issued in connection with the acquisition of the Intrarosa intangible asset	12,555	0
Contingent consideration accrued for the acquisition of the Intrarosa intangible asset	$ 18,600	$ 0