CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Product sales, net	$ 130,342	$ 102,983	$ 242,859	$ 192,547
Service revenues, net	28,023	24,379	54,955	43,898
License fee, collaboration and other revenues	29	57	53	273
Total revenues	158,394	127,419	297,867	236,718
Costs and expenses:
Cost of product sales	32,101	21,937	59,675	40,236
Cost of services	5,562	5,195	10,572	10,721
Research and development expenses	30,258	14,234	46,747	28,463
Acquired in-process research and development	5,845	0	65,845	0
Selling, general and administrative expenses	80,988	51,924	151,412	115,098
Impairment charges of intangible assets	0	15,963	0	15,963
Restructuring expenses	0	89	0	712
Total costs and expenses	154,754	109,342	334,251	211,193
Operating income (loss)	3,640	18,077	(36,384)	25,525
Other (expense) income:
Interest expense	(17,256)	(18,250)	(35,556)	(36,693)
Loss on debt extinguishment	(9,516)	0	(9,516)	0
Interest and dividend income	663	773	1,695	1,481
Other (expense) income	(69)	0	(43)	220
Total other (expense) income	(26,178)	(17,477)	(43,420)	(34,992)
(Loss) income before income taxes	(22,538)	600	(79,804)	(9,467)
Income tax (benefit) expense	(8,472)	1,196	(29,178)	(1,344)
Net loss	$ (14,066)	$ (596)	$ (50,626)	$ (8,123)
Net loss per share:
Basic (in usd per share)	$ (0.40)	$ (0.02)	$ (1.46)	$ (0.24)
Diluted (in usd per share)	$ (0.40)	$ (0.02)	$ (1.46)	$ (0.24)
Weighted average shares outstanding used to compute net loss per share:
Basic (in shares)	35,145	34,223	34,764	34,481
Diluted (in shares)	35,145	34,223	34,764	34,481