Equity-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2017

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of details regarding stock options granted under equity incentive plans

The following table summarizes stock option activity for the six months ended June 30, 2017:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2016	2,158,822		5,200	134,181		814,975		3,113,178
Granted	685,817		—	—		28,100		713,917
Exercised	(17,590	)	—	—		—		(17,590	)
Expired or terminated	(202,472	)	—	(1,031	)	(58,875	)	(262,378	)
Outstanding at June 30, 2017	2,624,577		5,200	133,150		784,200		3,547,127

Summary of details regarding restricted stock units granted under equity incentive plans

The following table summarizes RSU activity for the six months ended June 30, 2017:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2016	773,804		—	27,694		135,456		936,954
Granted	779,776		—	—		6,800		786,576
Vested	(332,417	)	—	(12,831	)	(31,497	)	(376,745	)
Expired or terminated	(126,374	)	—	(501	)	(7,818	)	(134,693	)
Outstanding at June 30, 2017	1,094,789		—	14,362		102,941		1,212,092

Schedule of equity-based compensation expense

Equity-based compensation expense for the six months ended June 30, 2017 and 2016 consisted of the following (in thousands):

	Three Months Ended June 30,						Six Months Ended June 30,
	2017			2016			2017			2016
Cost of product sales and services	$	129		$	(44	)	$	258		$	277
Research and development	1,095			968			1,851			1,725
Selling, general and administrative	4,667			4,254			9,560			9,339
Total equity-based compensation expense	5,891			5,178			11,669			11,341
Income tax effect	(1,717		)	(1,394		)	(3,321		)	(3,068		)
After-tax effect of equity-based compensation expense	$	4,174		$	3,784		$	8,348		$	8,273