CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Cash flows from operating activities:
Net loss	$ (36,560,000)	$ (7,527,000)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	27,994,000	19,644,000
Provision for bad debt expense	590,000	2,209,000
Amortization of premium/discount on purchased securities	113,000	177,000
Non-cash equity-based compensation expense	5,778,000	6,160,000
Amortization of debt discount and debt issuance costs	3,209,000	2,937,000
Gains on investments, net	(143,000)	0
Change in fair value of contingent consideration	1,043,000	5,056,000
Deferred income taxes	(21,192,000)	(1,469,000)
Changes in operating assets and liabilities:
Accounts receivable, net	6,553,000	715,000
Inventories	(403,000)	(2,157,000)
Receivable from collaboration	0	246,000
Prepaid and other current assets	1,523,000	(3,078,000)
Accounts payable and accrued expenses	(4,622,000)	(6,647,000)
Deferred revenues	2,067,000	9,717,000
Other assets and liabilities	(486,000)	593,000
Net cash (used in) provided by operating activities	(14,536,000)	26,576,000
Cash flows from investing activities:
Proceeds from sales or maturities of investments	128,512,000	25,500,000
Purchase of investments	(129,241,000)	(63,413,000)
Change in restricted cash	100,000	0
Capital expenditures	(658,000)	(681,000)
Net cash used in investing activities	(1,287,000)	(38,594,000)
Cash flows from financing activities:
Long-term debt principal payments	(4,375,000)	(4,375,000)
Payment of contingent consideration	(83,000)	(65,000)
Payments for repurchases of common stock	0	(7,562,000)
Proceeds from the exercise of stock options	152,000	400,000
Payments of employee tax withholding related to equity-based compensation	(1,322,000)	(1,696,000)
Net cash used in financing activities	(5,628,000)	(13,298,000)
Net decrease in cash and cash equivalents	(21,451,000)	(25,316,000)
Cash and cash equivalents at beginning of the period	274,305,000	228,705,000
Cash and cash equivalents at end of the period	252,854,000	203,389,000
Supplemental data for cash flow information:
Cash paid for taxes	208,000	2,400
Cash paid for interest	$ 26,195,000	$ 27,964