Equity-Based Compensation - Equity-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Equity-based compensation expense
Total equity-based compensation expense	$ 5,778	$ 6,160
Income tax effect	(1,605)	(1,674)
After-tax effect of equity-based compensation expense	4,173	4,486
Cost of product sales
Equity-based compensation expense
Total equity-based compensation expense	129	320
Research and development
Equity-based compensation expense
Total equity-based compensation expense	756	756
Selling, general and administrative
Equity-based compensation expense
Total equity-based compensation expense	$ 4,893	$ 5,084