CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Product sales, net	$ 112,517,000	$ 89,564,000
Service revenues, net	26,931,000	19,520,000
License fee, collaboration and other revenues	24,000	216,000
Total revenues	139,472,000	109,300,000
Costs and expenses:
Cost of product sales	27,573,000	18,300,000
Cost of services	5,010,000	5,526,000
Research and development expenses	16,489,000	14,229,000
Acquired in-process research and development	60,000,000	0
Selling, general and administrative expenses	70,424,000	63,175,000
Restructuring expenses	0	622,000
Total costs and expenses	179,496,000	101,852,000
Operating income (loss)	(40,024,000)	7,448,000
Other income (expense):
Interest expense	(18,300,000)	(18,443,000)
Interest and dividend income	1,031,000	708,000
Gains on investments, net	27,000	0
Other income (expense)	0	220,000
Total other income (expense)	(17,242,000)	(17,515,000)
Loss before income taxes	(57,266,000)	(10,067,000)
Income tax benefit	(20,706,000)	(2,540,000)
Net loss	$ (36,560,000)	$ (7,527,000)
Net loss per share:
Basic (in usd per share)	$ (1.06)	$ (0.22)
Diluted (in usd per share)	$ (1.06)	$ (0.22)
Weighted average shares outstanding used to compute net loss per share:
Basic (in shares)	34,378	34,739
Diluted (in shares)	34,378	34,739